Once in a Lifetime: The Best of Talking Heads is a compilation album by Talking Heads.

Track listing
“Psycho Killer”
“Take Me to the River”
“Once in a Lifetime”
“Burning Down the House”
“This Must Be the Place (Naive Melody)”
“Slippery People (Live)”
“Life During Wartime (Live)”
“And She Was”
“Road to Nowhere”
“Wild Wild Life”
“Blind”
“(Nothing But) Flowers”
“Sax and Violins”
“Lifetime Piling Up”